Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness
Delirium is the most common manifestation of acute brain dysfunction during critical illness, affecting 50 to 75% of patients who receive mechanical ventilation in an intensive care unit (ICU). Patients with delirium have higher mortality, longer periods of mechanical ventilation and hospital stays, higher costs, and a higher risk of long-term cognitive impairment9-11 than patients who do not have delirium. Delirium also interferes with medical care. Hyperactive delirium can lead to unplanned removal of devices, whereas hypoactive delirium prevents participation in nursing interventions, physical therapy, and occupational therapy…
